Articles | Published Articles
The p75 neurotrophin receptor inhibitor, LM11A 31, ameliorates acute stroke injury and modulates astrocytic proNGF
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Sanaz Nasoohi, Pargol Tayefeh Ghahremani, Parsa Alehossein, Siyamak Elyasizadeh, Soha BaniArdalan, Saifudeen Ismael, Hossein Vat
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Experimental Neurology
The precursor form of nerve growth factor (proNGF) is essential to maintain NGF survival signaling. ProNGF is also among endogenous ligands for p75 neurotrophin receptor (p75ntr). Mounting evidence implies that p75ntr signaling contributes to neural damage in ischemic stroke. The present study examines the therapeutic effect of the p75ntr modulator LM11A-31. Adult mice underwent transient distal middle cerebral artery occlusion (t-dMCAO) followed by LM11A-31 treatment (25 mg/kg, i.p., twice daily)...
